期刊
VIRUSES-BASEL
卷 10, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/v10010040
关键词
gene targeting; CRISPR-Cas; host genes; virus; antiviral strategy
类别
资金
- Natural Science Foundation of China [81401659]
- China Postdoctoral Science Foundation [2015T80838, 2014M560622]
- China National Special Research Program of Major Infectious Diseases [2014ZX10001003]
- Hubei Provincial Science & Technology Innovation Team Grant [2012FFA043]
Currently, a new gene editing toolthe Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) associated (Cas) systemis becoming a promising approach for genetic manipulation at the genomic level. This simple method, originating from the adaptive immune defense system in prokaryotes, has been developed and applied to antiviral research in humans. Based on the characteristics of virus-host interactions and the basic rules of nucleic acid cleavage or gene activation of the CRISPR-Cas system, it can be used to target both the virus genome and host factors to clear viral reservoirs and prohibit virus infection or replication. Here, we summarize recent progress of the CRISPR-Cas technology in editing host genes as an antiviral strategy.
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