期刊
VIRUSES-BASEL
卷 10, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/v10060278
关键词
hMPV; SH protein; plasmacytoid dendritic cells; type I IFN
类别
资金
- National Institute of Health [R01 AI079246, P01 AI062885, P30 ES006676]
- MedImmune fellowship from UTMB
- James W. McLaughlin Fellowship Fund from UTMB
Human metapneumovirus (hMPV), a leading cause of respiratory tract infections in infants, encodes a small hydrophobic (SH) protein of unknown function. Here we show that infection of plasmacytoid dendritic cells (pDCs) with a recombinant virus lacking SH expression (rhMPV-SH) enhanced the secretion of type I interferons (IFNs), which required TLR7 and MyD88 expression. HMPV SH protein inhibited TLR7/MyD88/TRAF6 signaling leading to IFN gene transcription, identifying a novel mechanism by which paramyxovirus SH proteins modulate innate immune responses.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据