期刊
VIRUSES-BASEL
卷 10, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/v10050246
关键词
HSV-2; reactivation; guinea pig; fluorescent HSV-2; mNeonGreen; vaginal infection model
类别
资金
- NIAID NIH HHS [K22 AI097299] Funding Source: Medline
- NINDS NIH HHS [R01 NS104351] Funding Source: Medline
Fluorescent herpes simplex viruses (HSV) are invaluable tools for localizing virus in cells, permitting visualization of capsid trafficking and enhancing neuroanatomical research. Fluorescent viruses can also be used to study virus kinetics and reactivation in vivo. Such studies would be facilitated by fluorescent herpes simplex virus recombinants that exhibit wild-type kinetics of replication and reactivation and that are genetically stable. We engineered an HSV-2 strain expressing the fluorescent mNeonGreen protein as a fusion with the VP26 capsid protein. This virus has normal replication and in vivo recurrence phenotypes, providing an essential improved tool for further study of HSV-2 infection.
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