期刊
VIRUSES-BASEL
卷 10, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/v10070362
关键词
tick; flavivirus; saliva; skin; cutaneous; interface; feeding
类别
资金
- NIH/NIAID [R01AI127771, R21AI113128]
- Kempner postdoctoral fellowship
Tick-borne viral diseases continue to emerge in the United States, as clearly evident from the increase in Powassan encephalitis virus, Heartland virus, and Bourbon virus infections. Tick-borne flaviviruses (TBFVs) are transmitted to the mammalian host along with the infected tick saliva during blood-feeding. Successful tick feeding is facilitated by a complex repertoire of pharmacologically active salivary proteins/factors in tick saliva. These salivary factors create an immunologically privileged micro-environment in the host's skin that influences virus transmission and pathogenesis. In this review, we will highlight tick determinants of TBFV transmission with a special emphasis on tick-virus-host interactions at the cutaneous interface.
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