期刊
ZOONOSES AND PUBLIC HEALTH
卷 65, 期 4, 页码 454-458出版社
WILEY
DOI: 10.1111/zph.12456
关键词
antibiotic resistance; Desmodus rotundus; ESBL-producing Escherichia coli; multilocus sequence typing; Peru; plasmid typing
资金
- Wellcome Trust [102507/Z/13/Z]
- Royal Society [102507/Z/13/Z]
- CONCYTEC-UK Embassy [003-2016-FONDECYT]
- Wellcome Trust [102507/Z/13/Z] Funding Source: Wellcome Trust
- MRC [MC_UU_12014/8] Funding Source: UKRI
Antibiotic resistance mediated by bacterial production of extended-spectrum beta-lactamase (ESBL) is a global threat to public health. ESBL resistance is most commonly hospital-acquired; however, infections acquired outside of hospital settings have raised concerns over the role of livestock and wildlife in the zoonotic spread of ESBL-producing bacteria. Only limited data are available on the circulation of ESBL-producing bacteria in animals. Here, we report ESBL-producing Escherichia coli in wild common vampire bats Desmodus rotundus and livestock near Lima, Peru. Molecular analyses revealed that most of this resistance resulted from the expression of bla(CTX-M-15) genes carried by plasmids, which are disseminating worldwide in hospital settings and have also been observed in healthy children of Peru. Multilocus sequence typing showed a diverse pool of E.coli strains carrying this resistance that were not always host species-specific, suggesting sharing of strains between species or infection from a common source. This study shows widespread ESBL resistance in wild and domestic animals, supporting animal communities as a potential source of resistance. Future work is needed to elucidate the role of bats in the dissemination of antibiotic-resistant strains of public health importance and to understand the origin of the observed resistance.
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