期刊
NEUROREHABILITATION
卷 30, 期 4, 页码 323-328出版社
IOS PRESS
DOI: 10.3233/NRE-2012-0762
关键词
Diffusion tensor imaging; brain injury; diffuse axonal injury; uncinate fasciculus
资金
- Ministry of Education, Science and Technology of Korea [11-1T-01]
The recent development of diffusion tensor imaging (DTI) allows visualization and estimation of the uncinate fascicul us (UF). We investigated injuries of the UF in patients with diffuse axonal injury (DAI) who showed no specific lesions except for DAI lesions on conventional brain MRI. Twenty-one chronic patients with DAI, and 21 age- and sex-matched normal control subjects were recruited for this study. Diffusion tensor images were acquired using a sensitivity-encoding head coil at 1.5 T and the UF was reconstructed using DTI-Studio software. Fractional anisotropy (FA), apparent diffusion coefficient (ADC) value, and fiber number of the UF were measured. In the DAI group, the FA values and fiber numbers were significantly decreased compared to those of the control group (P < 0.05). The FA value and fiber number decreased 8.4% and 26.5% in the DAI group compared to those of the control group. By contrast, the ADC value did not show any difference between the DAI and control groups (P > 0.05). Changes in the DTI parameters of the DAI group appeared to indicate neural injury of the UF. We believe that DTI can be a useful evaluation tool for detecting hidden neural injuries of UF in patients with DAI.
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