Mangostanaxanthone VII, a new cytotoxic xanthone from Garcinia mangostana

Garcinia mangostana L. (the queen of fruits, mangosteen, family Guttiferae) is a wealthy source of xanthones. The CHCl3 soluble fraction of the air-dried pericarps of G. mangostana provided a new xanthone: mangostanaxanthone VII (5), along with four known xanthones: mangostanaxanthones I (1) and II (2), gartanin (3) and gamma-mangostin (4). The structural verification of these metabolites was achieved by different spectral techniques, including UV, IR, 1D and 2D NMR and HRESIMS. The new metabolite was assessed for cytotoxic potential, using sulforhodamine B (SRB) assay towards the A549 and MCF-7 cancer cell lines. Moreover, its antimicrobial effects were evaluated against various bacterial and fungal strains, using agar disc diffusion assay. Mango-stanaxanthone VII showed moderate cytotoxic activity against the A549 and MCF7 cell lines with IC(50)s 26.1 and 34.8 mu M, respectively, compared with doxorubicin (0.74 and 0.41 mu M, respectively).