期刊
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
卷 34, 期 3, 页码 -出版社
SPRINGER
DOI: 10.1007/s11274-018-2425-8
关键词
Mannitol; Fermentation; Strain development; Regulation; Metabolic flux
资金
- Key Science and Technology Project of Jiangsu Province [BE2016389]
- Jiangsu Key Lab of Biomass-based Green Fuels and Chemicals Foundation [JSBEM2016010]
Mannitol has been widely used in fine chemicals, pharmaceutical industries, as well as functional foods due to its excellent characteristics, such as antioxidant protecting, regulation of osmotic pressure and non-metabolizable feature. Mannitol can be naturally produced by microorganisms. Compared with chemical manufacturing, microbial production of mannitol provides high yield and convenience in products separation; however the fermentative process has not been widely adopted yet. A major obstacle to microbial production of mannitol under industrial-scale lies in the low economical efficiency, owing to the high cost of fermentation medium, leakage of fructose, low mannitol productivity. In this review, recent advances in improving the economical efficiency of microbial production of mannitol were reviewed, including utilization of low-cost substrates, strain development for high mannitol yield and process regulation strategies for high productivity.
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