期刊
VIRUS RESEARCH
卷 244, 期 -, 页码 90-98出版社
ELSEVIER
DOI: 10.1016/j.virusres.2017.11.014
关键词
Adenovirus; Adipose tissue; Inflammation; Obesity; Mouse model
类别
资金
- American Heart Association [16GRNT30250013]
- University of Michigan Charles Woodson Accelerator Award
Human adenovirus (HAdV) type 36 seropositivity has been linked to obesity in humans. That link is supported by a small number of studies using HAdV-36 infection of animals that are not natural hosts for HAdVs. In this study, we infected mice with mouse adenovirus type 1 (MAV-1), a mouse pathogen, to determine whether MAV-1 infected adipose tissue and was associated with adipose tissue inflammation and obesity. We detected MAV-1 in adipose tissue during acute MAV-1 infection, but we did not detect virus-induced increases in adipose tissue cytokine expression or histological evidence of adipose tissue inflammation during acute infection. MAV-1 did not persist in adipose tissue at later times, and we did not detect long-term adipose inflammation, increased adipose tissue mass, or body weight in infected mice. Our data indicate that MAV-1 is not associated with obesity in infected mice.
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