期刊
VIRUS RESEARCH
卷 248, 期 -, 页码 63-70出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.virusres.2018.02.017
关键词
Avian leukosis virus subgroup J; Baicalin; Virus infection; Inhibition
类别
资金
- Key Program of NSFC-Henan Joint Fund [U1604232]
- National key research and development program [2017YFD0500702]
- National Natural Science Foundation of China [31772734]
- NCFC-RCUK-BBSRC [31761133002]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Jiangsu Co-innovation Centre for the Prevention and Control of Important Animal Infectious Diseases and Zoonoses
Avian leukosis virus subgroup J (ALV-J) can cause great economic losses to the poultry industry worldwide. Baicalin, one of the flavonoids present in S.baicalensis Georgi, has been shown to have antiviral activities. To investigate whether baicalin has antiviral effects on the infection of ALV-J in DF-1 cells, the cells were treated with baicalin at different time points. We found that baicalin could inhibit viral mRNA, protein levels and overall virus infection in a dose- and time-dependent manner using a variety of assays. Baicalin specifically targeted virus internalization and reduced the infectivity of ALV-J particles, but had no effect on the levels of major ALV-J receptor and virus binding to DF-1 cells. Collectively, these results suggest that baicalin might have potential to be developed as a novel antiviral agent for ALV-J infection.
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