4.4 Article

Maternal immunization with a recombinant adenovirus-expressing fusion protein protects neonatal cotton rats from respiratory syncytia virus infection by transferring antibodies via breast milk and placenta

期刊

VIROLOGY
卷 521, 期 -, 页码 181-189

出版社

ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2018.06.009

关键词

RSV; Maternal; Adenovirus; Vaccine

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资金

  1. Taiwan Ministry of Science Technology [MOST 103-2311-B-400-004-MY3]

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We evaluated the efficacy of a recombinant adenovirus that expresses a membrane-truncated respiratory syncytial virus (RSV) fusion protein (Ad-F0 Delta TM) in newborns via maternal immunization (MI) of pregnant cotton rats. Intranasal Ad-F0 Delta TM immunization was given to pregnant female rats, and MI-newborn rats were then challenged intranasally with RSV. Anti-RSV IgGs were observed in the serum of MI-newborn rats after birth. The pulmonary viral loads in Ad-F0 Delta TM vs. control vector, Ad-LacZ, and MI-newborns on day 3 post-challenge were reduced by 4 log(10)/g lung. The neutralizing antibody remained for up to 3 weeks in the serum of MI-newborns, which is when weaning began. Ad-F0 Delta TM protected MI-newborns from RSV challenge for 1 week. Vertical transferred protective antibodies were examined in the breast milk and placenta as well. Finally, anti-RSV immunity was not boosted but was only primed during the next RSV exposure in Ad-F0 Delta TM-MI-newborns. Maternal Ad-F0 Delta TM immunization provides acute protection against RSV infection in neonates.

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