期刊
VIROLOGY
卷 513, 期 -, 页码 29-42出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2017.10.007
关键词
Influenza A virus; Avian influenza; Poultry; Chicken; Endothelial cells; Virus-host interactions; Cell tropism; Pathogenesis; Innate immunity; Inflammation
类别
资金
- INRA Animal Health Department (Departement Sante animale)
- Region Centre
- Partenariat Hubert Curien (PHC) Van Gogh program [FLUAVEC 35533SF]
- National Health and Medical Research Council of Australia [APP1054081]
Endotheliotropism is a hallmark of gallinaceous poultry infections with highly pathogenic avian influenza (HPAI) viruses and a feature that distinguishes HPAI from low pathogenic avian influenza (LPAI) viruses. Here, we used chicken aortic endothelial cells (chAEC) as a novel in vitro infection model to assess the susceptibility, permissiveness, and host response of chicken endothelial cells (EC) to infections with avian influenza (AI) viruses. Our data show that productive replication of AI viruses in chAEC is critically determined by hemagglutinin cleavability, and is thus an exclusive trait of FIPAI viruses. However, we provide evidence for a link between limited (i.e. trypsin-dependent) replication of certain LPAI viruses, and the viruses' ability to dampen the antiviral innate immune response in infected chAEC. Strikingly, this cell response pattern was also detected in HPAI virus-infected chAEC, suggesting that viral innate immune escape might be a prerequisite for robust AI virus replication in chicken EC.
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