期刊
VIRAL IMMUNOLOGY
卷 31, 期 1, 页码 23-33出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/vim.2017.0050
关键词
veterinary; vaccines; protection; innate immunity; humoral immunity
资金
- Canadian Poultry Research Council
- Alberta Agriculture and Forestry
- Natural Sciences and Engineering Council (NSERC) of Canada
- MITACS
- Institute of Poultry Technologies, Alberta, Canada
- Saskatchewan Agriculture, Canada
- Egyptian government
Commercial broiler and layer chickens are heavily vaccinated against economically important viral diseases with a view of preventing morbidity, mortality, and production impacts encountered during short production cycles. Hatchery vaccination is performed through in ovo embryo vaccination prehatch or spray and subcutaneous vaccinations performed at the day of hatch before the day-old chickens are being placed in barns with potentially contaminated environments. Commercially, multiple vaccines (e.g., live, live attenuated, and viral vectored vaccines) are available to administer through these routes within a short period (embryo day 18 prehatch to day 1 posthatch). Although the ability to mount immune response, especially the adaptive immune response, is not optimal around the hatch, it is possible that the efficacy of these vaccines depends partly on innate host responses elicited in response to replicating vaccine viruses. This review focuses on the current knowledge of hatchery vaccination in poultry and potential mechanisms of hatchery vaccine-mediated protective responses and limitations.
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