期刊
JOURNAL OF PHARMACY AND BIOALLIED SCIENCES
卷 4, 期 4, 页码 327-332出版社
MEDKNOW PUBLICATIONS & MEDIA PVT LTD
DOI: 10.4103/0975-7406.103272
关键词
DNA damage; herbal preparation; mitochondrial mass; radioprotection; ROS
Objectives: Preparations of herbal drugs have drawn considerable interest in scientific community in recent years for the treatment of several stress related health problems including radiation-injury. Materials and Methods: An aqueous extract from Valeriana wallichii containing hesperidin as one of its major constituent was evaluated for its ability to protect against radiation-injury in model systems like plasmid deoxyribonucleic acid (DNA) and cultured human fibroblast cells. Results: The extract was found to significantly counter radiation-induced free radicals at 4 h after 5 Gy irradiation, reduced prolonged oxidative stress led increase in mitochondrial mass, enhanced reproductive viability of cultured cells and protected against radiation-induced DNA damage in solution. Discussion: Further studies are required to validate the radioprotective ability of the extract and to develop a safer radioprotective agent.
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