期刊
NATURE REVIEWS CANCER
卷 12, 期 10, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc3344
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- Associazione Italiana per la Ricerca sul Cancro Funding Source: Custom
The generation of DNA lesions and the resulting activation of DNA damage response (DDR) pathways are both affected by the chromatin status at the site of damaged DNA. In turn, DDR activation affects the chromatin at both the damaged site and across the whole genome. Cellular senescence and cancer are associated with the engagement of the DDR pathways and with profound chromatin changes. In this Opinion article, we discuss the interplay between chromatin and DDR factors in the context of cellular senescence that is induced by oncogenes and in cancer.
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