期刊
VACCINE
卷 36, 期 11, 页码 1389-1397出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2018.01.087
关键词
East Coast fever; Vaccinology; Subunit vaccine; Parasite; p67C antigen; Theileria parva
资金
- Bill & Melinda Gates Foundation United States
- Department for International Development of the United Kingdom [OPP1078791]
- CGIAR Research Program on Livestock
- International Livestock Research Institute (ILRI)
- United States Department of Agriculture - Agricultural Research Service [58-5348-2-117F]
East Coast fever (ECF) is a lymphoproliferative disease caused by the tick-transmitted protozoan parasite Theileria parva. ECF is one of the most serious cattle tick-borne diseases in Sub-Saharan Africa. We have previously demonstrated that three doses of the C-terminal part of the sporozoite protein p67 (p67C) adjuvanted with ISA206VG confers partial protection against ECF at a herd level. We have tested the efficacy of two doses of this experimental vaccine, as reducing the vaccination regimen would facilitate its deployment in the field. We reconfirm that three antigen doses gave a significant level of protection to severe disease (46%, ECF score < 6) when compared with the control group, while two doses did not (23%). Animals receiving three doses of p67C developed higher antibody titers and CD4* T-cell proliferation indices, than those which received two doses. A new panel of immune parameters were tested in order to identify factors correlating with protection: CD4(+) proliferation index, total IgG, IgG1, IgG2 and IgM half maximal titers and neutralization capacity of the sera with and without complement. We show that some of the cellular and humoral immune responses provide preliminary correlates of protection. (C) 2018 The Authors. Published by Elsevier Ltd.
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