期刊
VACCINE
卷 36, 期 12, 页码 1570-1576出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2018.02.015
关键词
Foot-and-Mouth Disease; In vivo protection; O-1/Campos vaccines; Vaccine matching
In 2010 serotype O foot-and-mouth disease virus of the Mya98 lineage/SEA topotype spread into most East Asian countries. During 2010-2011 it was responsible for major outbreaks in the Republic of Korea where a monovalent O/Manisa vaccine (belonging to the ME-SA topotype) was applied to help control the outbreaks. Subsequently, all susceptible animals were vaccinated every 6 months with a vaccine containing the O/Manisa antigen. Despite vaccination, the disease re-occurred in 2014 and afterwards almost annually. This study focuses on the in vivo efficacy in pigs of a high quality monovalent commercial O-1/Campos vaccine against heterologous challenge with a representative 2015 isolate from the Jincheon Province of the Republic of Korea. Initially, viral characterizations and r(1) determinations were performed on six viruses recovered in that region during 2014-2015, centering on their relationship with the well characterized and widely available O-1/Campos vaccine strain. Genetic and antigenic analysis indicated a close similarity among 2014-2015 Korean isolates and with the previous 2010 virus, with distinct differences with the O-1/Campos strain. Virus neutralisation tests using O-1/Campos cattle and pig post vaccination sera and recent Korean outbreak viruses predicted acceptable cross-protection after a single vaccination, as indicated by r(1) values, and in pigs, by expectancy of protection. In agreement with the in vitro estimates, in vivo challenge with a selected field isolate indicated that O-1/Campos primo vaccinated pigs were protected, resulting in a PD50 value of nearly 10. The results indicated that good quality oil vaccines containing the O-1/Campos strain can successfully be used against isolates belonging to the O Mya98/SEA topotype. (C) 2018 Elsevier Ltd. All rights reserved.
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