期刊
ULTRASOUND IN MEDICINE AND BIOLOGY
卷 44, 期 7, 页码 1544-1555出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ultrasmedbio.2018.03.020
关键词
Myocardial infarction; Cardiac remodeling; Echocardiography; Method validation; Mouse
资金
- German Research Foundation [CRC 1116, TP A06, TP S01]
Although echocardiography is commonly used to analyze cardiac function in small animal models of cardiac remodeling after myocardial infarction, the different echocardiographic methods are validated poorly. End-diastolic volume, end-systolic volume and ejection fraction were analyzed using either standard single-plane analysis from parasternal long-axis B-mode views (PSLAX) or the bi-plane Simpson method (using PSLAX and three short-axis views) and validated using magnetic resonance imaging as standard. Ejection fraction measured by PSLAX was moderately correlated with a coefficient of R-2 = 049. The standard deviation of residuals was 9.91. Simpson analysis revealed an improved correlation coefficient of R-2 = 0.77 and a reduction in standard deviation of residuals by 45% (5.45 vs. 9.92, p = 0.014). Subgroup analysis revealed that the high variation in PSLAX is due to changes in ventricular geometry after myocardial infarction. Our results indicate that the bi-plane Simpson method is advantageous for the assessment of cardiac function after myocardial infarction. (E-mail: heinen@hhu.de) (C) 2018 World Federation for Ultrasound in Medicine & Biology. All rights reserved.
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