The new approach to organocatalysts. Synthesis of a library of N-lipidated oligopeptides immobilized on cellulose and screening of their catalytic activity

A library of N-lipidated tripeptides was prepared from amino acids characteristic of the active sites of hydrolytic enzymes: Ser, His, and Glu immobilized in the highly regular pattern on the cellulose surface according to TASP concept. It was found that such structures can accelerate the rate of hydrolysis of p-nitrophenyl esters of N-protected dipeptides.