期刊
TRENDS IN NEUROSCIENCES
卷 41, 期 2, 页码 67-70出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2017.11.003
关键词
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资金
- European Union's Horizon Research and Innovation Programme [720270]
The structural identification of the cationic channel of the acetylcholine nicotinic receptor involved its biochemical tagging by channel blockers, followed by site-directed mutagenesis analyses reported in two papers in 1988. The ion channel was demonstrated to be lined by the transmembrane segment MII, in which the binding sites of channel blockers are framed by anionic rings.
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