期刊
TRENDS IN MOLECULAR MEDICINE
卷 24, 期 9, 页码 794-804出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2018.06.008
关键词
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资金
- NIAID NIH HHS [T32 AI007496, R01 AI043596, K08 AI119181, T35 AI060528] Funding Source: Medline
Inflammatory mediators affect the brain during development. Neurodevelopmental disorders such as autism spectrum disorders, cognitive impairment, cerebral palsy, epilepsy, and schizophrenia have been linked to early life inflammation. Recent advances have shown the effects of systemic inflammation on childrens neurodevelopment. We discuss the potential mechanisms by which inflammatory molecules can exert their effects on the developing brain and consider the roles of MHC class I molecules, the HPA axis, glial cells, and monoamine metabolism. Methods to prevent the effects of cytokine imbalance may lead to the development of new therapeutics for neuropsychiatric disorders. Future research should focus on identifying at-risk individuals and early effective interventions to prevent long-term neurodevelopmental disabilities.
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