期刊
TRENDS IN IMMUNOLOGY
卷 39, 期 9, 页码 734-747出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2018.06.003
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资金
- Medical Research Council [MR/L018284/1] Funding Source: Medline
- MRC [MR/L018284/1] Funding Source: UKRI
Cellular immunity is governed by a complex network of migratory cues that enable appropriate immune cell responses in a timely and spatially controlled fashion. This review focuses on the chemokines and their receptors regulating the steady-state localisation of immune cells within healthy peripheral tissues. Steady-state immune cell traffic is not well understood but is thought to involve constitutive (homeostatic) chemokines. The recent discovery of tissue-resident memory T cells (T RM cells) illustrates our need for understanding how chemokines control immune cell mobilisation and/or retention. These studies will be critical to unravel novel pathways for preserving tissue function (aging) and preventing tissue disease (vaccination).
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