期刊
TRENDS IN IMMUNOLOGY
卷 39, 期 8, 页码 644-655出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2018.06.001
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资金
- NIH [R01 CA201246, R01 CA198533, S10 RR027619]
- Breast Cancer Research Foundation [BCRF-17-053]
- Chemotherapy Foundation
- Anna-Maria and Stephen Kellen Foundation
- CRIS FEOR Foundation against cancer
Radiotherapy has been used for more than a hundred years as a local tumor treatment. The occurrence of systemic antitumor effects manifesting as regression of tumors outside of the irradiated field (abscopal effect) was occasionally observed but deemed too rare and unpredictable to be a therapeutic goal. This has changed with the advent of immunotherapy. Remarkable systemic effects have been observed in patients receiving radiotherapy to control tumors that were progressing during immune checkpoint blockade, stimulating interest in using radiation to overcome primary and acquired cancer resistance to immunotherapy. Here, we review the immunological mechanisms that are responsible for the ability of focal radiation to promote antitumor T cell responses that mediate tumor rejection and, in some cases, result in systemic effects.
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