期刊
TRENDS IN IMMUNOLOGY
卷 39, 期 2, 页码 123-134出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2017.11.002
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资金
- US National Institutes of Health [AI101935, AI124346, AR056296, CA163507]
- American Lebanese Syrian Associated Charities
Z-DNA-binding protein 1 (ZBP1), initially reported as an interferon (IFN)-inducible tumor-associated protein, harbors nucleic acid-binding domains for left-handed helix (Z-form) and receptor-interacting protein homotypic interaction motif (RHIM) domains for protein homotypic interactions. Recent studies have identified ZBP1 as an innate sensor of viral infections and a target of viral evasion strategies, regulating cell death, inflammasome activation, and proinflammatory responses. ZBP1 also functions during development and can trigger perinatal lethality when its RHIM-dependent interactions are not restricted. Here we review the history and emergence of ZBP1 as a pathogen sensor and a central regulator of cell death and inflammatory responses. We also discuss the gaps in our knowledge regarding the regulation and functions of ZBP1 and highlight potential avenues for future research.
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