期刊
TRENDS IN GENETICS
卷 34, 期 5, 页码 341-351出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2018.01.002
关键词
-
资金
- Intramural Research Program of the National Eye Institute [EY000450, EY000546]
For decades, RNA has served in a supporting role between the genetic carrier (DNA) and the functional molecules (proteins). It is finally time for RNA to take center stage in all aspects of biology. The retina provides a unique opportunity to dissect the molecular underpinnings of neuronal diversity and disease. Transcriptome profiles of the retina and its resident cell types have unraveled unique features of the RNA landscape. The discovery of distinct RNA molecules and the recognition that RNA processing is a major cause of retinal neuro-degeneration have prompted the design of biomarkers and novel therapeutic paradigms. We review here RNA biology as it pertains to the retina, emphasizing new avenues for investigations in development and disease.
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