期刊
TRENDS IN COGNITIVE SCIENCES
卷 22, 期 4, 页码 307-324出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tics.2018.02.002
关键词
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资金
- Natural Sciences and Engineering Research Council (NSERC) of Canada
- U.S. National Institute of Mental Health [R00MH103479, 1R01MH109954-01]
- Banting Postdoctoral Fellowship from the Canadian Institutes of Health Research (CIHR)
- National Institute of Child Health and Human Development [1F32HD087028-01]
- U.S. National Institute of Neurological Disorders and Stroke [R01NS078396]
- U.S. National Science Foundation [BCS1358907]
The human default network (DN) plays a critical role in internally directed cognition, behavior, and neuropsychiatric disease. Despite much progress with functional neuroimaging, persistent questions still linger concerning the electrophysiological underpinnings, fast temporal dynamics, and causal importance of the DN. Here, we review how direct intracranial recording and stimulation of the DN provides a unique combination of high spatiotemporal resolution and causal information that speaks directly to many of these outstanding questions. Our synthesis highlights the electrophysiological basis of activation, suppression, and connectivity of the DN, each key areas of debate in the literature. Integrating these unique electrophysiological data with extant neuroimaging findings will help lay the foundation for a mechanistic account of DN function in human behavior and cognition.
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