期刊
TRENDS IN CELL BIOLOGY
卷 28, 期 10, 页码 823-834出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2018.06.003
关键词
-
类别
资金
- Wellcome Trust Centre for Cell-Matrix Research [203128/Z/16/Z]
- BBSRC [1797330] Funding Source: UKRI
Cell migration controls developmental processes (gastrulation and tissue patterning), tissue homeostasis (wound repair and inflammatory responses), and the pathobiology of diseases (cancer metastasis and inflammation). Understanding how cells move in physiologically relevant environments is o major importance, and the molecular machinery behind cell movement has been well studied on 2D substrates, beginning over half a century ago. Studies over the past decade have begun to reveal the mechanisms that control cell motility within 3D microenvironments some similar to, and some highly divergent from those found in 2D. In this review we focus on migration and invasion of cells powered by actin, including formation of actin -rich protrusions at the leading edge, and the mechanisms that control nuclear movement in cells moving in a 3D matrix.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据