期刊
TRENDS IN CELL BIOLOGY
卷 28, 期 4, 页码 287-301出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2017.11.008
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资金
- NIH [R00DK094981, 1R01 CA218025-01, R00CA166527, 1R01 CA218036-01]
- CPRIT [150094, R1218]
- DOD [BC151465]
Long noncoding RNAs (lncRNAs), which are encoded by a vast less explored region of the human genome, may hold missing drivers of cancer and have gained attention recently as a potentially crucial layer of cancer cell regulation. lncRNAs are aberrantly expressed in a broad spectrum of cancers, and they play key roles in promoting and maintaining tumor initiation and progression, demonstrating their clinical potential as biomarkers and therapeutic targets. Recent discoveries have revealed that lncRNAs act as key signal transduction mediators in cancer signaling pathways by interacting with proteins, RNA, and lipids. Here, we review the mechanisms by which lncRNAs regulate cellular responses to extracellular signals and discuss their clinical potential as diagnostic indicators, stratification markers, and therapeutic targets of combinatorial treatments.
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