期刊
TRENDS IN CELL BIOLOGY
卷 28, 期 7, 页码 551-559出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2018.02.007
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资金
- NATIONAL CANCER INSTITUTE [R01CA228346, F30CA225110] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [T32HL007576] Funding Source: NIH RePORTER
- Howard Hughes Medical Institute Funding Source: Medline
- NCI NIH HHS [R01 CA228346] Funding Source: Medline
- NHLBI NIH HHS [T32 HL007576] Funding Source: Medline
Compared to their differentiated progeny, stem cells are often characterized by distinct metabolic landscapes that emphasize anaerobic glycolysis and a lower fraction of mitochondrial carbohydrate oxidation. Until recently, the metabolic program of stem cells had been thought to be a byproduct of the environment, rather than an intrinsic feature determined by the cell itself. However, new studies highlight the impact of metabolic behavior on the maintenance and function of intestinal stem cells and hair follicle stem cells. This Review summarizes and discusses the evidence that metabolism is not a mere consequence of, but rather influential on stem cell fate.
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