期刊
TRENDS IN CELL BIOLOGY
卷 28, 期 2, 页码 128-142出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2017.10.006
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Molecular oxygen (O-2) is a universal electron acceptor that enables ATP synthesis through mitochondrial respiration in all metazoans. Consequently, hypoxia (low O-2) has arisen as an organizing principle for cellular evolution, metabolism, and (patho) biology, eliciting a remarkable panoply of metabolic adaptations that trigger transcriptional, translational, post-translational, and epigenetic responses to determine cellular fitness. In this review we summarize current and emerging cell-autonomous molecular mechanisms that induce hypoxic metabolic reprogramming in health and disease.
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