期刊
TRENDS IN BIOTECHNOLOGY
卷 36, 期 1, 页码 15-29出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2017.09.006
关键词
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资金
- NIH [R01 DE025848, R01 DE018023]
- University of Pennsylvania Research Foundation
- NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH [R01DE025848, R01DE018023] Funding Source: NIH RePORTER
Nanomaterials have been developed for many biomedical applications, including medical imaging, drug delivery, and antimicrobial coatings. Intriguingly, nanoparticles can display 'enzyme-like' activity and have been explored as alternatives to natural enzymes in several industrial and energy-related applications. Recently, these catalytic nanomaterials with enzyme-mimetic properties have found new biomedical applications, from biofilm disruption to protection against neurodegeneration and tumor prevention. In this review we focus on recent in vivo studies demonstrating potential therapeutic uses of catalytic nanomaterials. We also provide insights about the relationships between catalytic activity, therapeutic efficacy, and biocompatibility that are critical for clinical translatability. Finally, we discuss current challenges and future directions for the use of these nanomaterials as novel platforms for the development of sustainable, affordable, and safe therapeutics.
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