期刊
TRENDS IN BIOTECHNOLOGY
卷 36, 期 9, 页码 898-906出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2018.04.005
关键词
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资金
- FNRS [MIS F.4515.17]
- National Science Foundation [IOS-1557796]
Plant pathogens pose a major threat to crop productivity. Typically, phytopathogens exploit plants' susceptibility (S) genes to facilitate their proliferation. Disrupting these S genes may interfere with the compatibility between the host and the pathogens and consequently provide broad-spectrum and durable disease resistance. In the past, genetic manipulation of such S genes has been shown to confer disease resistance in various economically important crops. Recent studies have accomplished this task in a transgene-free system using new genome editing tools, including clustered regularly interspaced palindromic repeats (CRISPR). In this Opinion article, we focus on the use of genome editing to target S genes for the development of transgene-free and durable disease-resistant crop varieties.
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