期刊
TRENDS IN BIOTECHNOLOGY
卷 36, 期 5, 页码 523-536出版社
CELL PRESS
DOI: 10.1016/j.tibtech.2018.01.004
关键词
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资金
- Australian Postgraduate Award (APA) PhD scholarship
- Wellcome Trust [WT1104797/Z/14/Z]
Better understanding how multidrug-resistant (MDR) bacteria can evade current and novel antibiotics requires a better understanding of the chemical biology of antibiotic action. This necessitates using new tools and techniques to advance our knowledge of bacterial responses to antibiotics, ideally in live cells in real time, to selectively investigate bacterial growth, division, metabolism, and resistance in response to antibiotic challenge. In this review, we discuss the preparation and biological evaluation of fluorescent antibiotics, focussing on how these reporters and assay methods can help elucidate resistance mechanisms. We also examine the potential utility of such probes for real-time in vivo diagnosis of infections.
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