期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 43, 期 6, 页码 452-468出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2018.03.004
关键词
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资金
- Inserm
- Aix-Marseille University
- ARC [PJA 20151203149]
- Plan Cancer [P036496]
- 'Equipe Labellisee Ligue Contre le Cancer' grants
- CONACYT [269449]
- 'Programa de Apoyo a Proyectos de investigacion e innovacion tecnologica' - Universidad Nacional Autonoma de Mexico (PAPIIT-UNAM) [IA206517]
- SEP-CONACYT-ANUIES-ECOS-NORD project [M17S02]
Gene expression in higher eukaryotes is precisely regulated in time and space through the interplay between promoters and gene-distal regulatory regions, known as enhancers. The original definition of enhancers implies the ability to activate gene expression remotely, while promoters entail the capability to locally induce gene expression. Despite the conventional distinction between them, promoters and enhancers share many genomic and epigenomic features. One intriguing finding in the gene regulation field comes from the observation that many core promoter regions display enhancer activity. Recent high-throughput reporter assays along with clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9-related approaches have indicated that this phenomenon is common and might have a strong impact on our global understanding of genome organisation and gene expression regulation.
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