期刊
TRANSPLANT INFECTIOUS DISEASE
卷 20, 期 3, 页码 -出版社
WILEY
DOI: 10.1111/tid.12878
关键词
cystic fibrosis; isavuconazole; lung transplant; mucormycosis; pharmacokinetics
Previous studies of patients with cystic fibrosis (CF) treated with azole antifungals have shown altered pharmacokinetics relative to healthy patients. Data regarding the pharmacokinetic profile of isavuconazole in patients with CF undergoing lung transplantation are currently not available. Serum trough concentrations assessed in a single CF patient following transplant revealed significantly lower values relative to available literature. Larger studies are required to validate CF population pharmacokinetics of isavuconazole.
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