期刊
TRANSLATIONAL ONCOLOGY
卷 11, 期 2, 页码 487-497出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.tranon.2018.02.002
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资金
- National Science and Technology Major Project of the Ministry of Science and Technology of China [2017ZX09304025]
- Science and Technology Plan Project of Liaoning Province [2015020457]
- National Natural Science Foundation of China [81572374, 81372547, 81201615]
- Liaoning Province Department of Education [LZ2015073]
- Foundation for Selected Overseas Chinese Scholar
- Key Research and Development Program of Shenyang [17-230-9-01]
The C-X-C motif chemokine receptor 4 (CXCR4) pathway can promote tumor metastasis but is dependent on cross talk with other signaling pathways. The MET proto-oncogene (c-MET) participates in metastasis and is highly expressed in gastric cancer. However, the relationship between CXCR4 and c-MET signaling and their mechanisms of action in gastric cancer metastasis remain unclear. In this study, in vitro experiments demonstrated that C-X-C motif chemokine ligand 12 (CXCL12)/CXCR4 induces epithelial-mesenchymal transition (EMT) and promotes migration in gastric cancer cells, which is accompanied by c-MET activation. These phenomena were reversed by c-MET inhibition. Further investigation revealed that c-MET activation correlated with its interaction with caveolin 1 in lipid rafts, induced by CXCL12. In clinical samples, we observed a significant positive association between CXCR4 expression and c-MET phosphorylation (r = 0.259, P =.005). Moreover, samples expressing both receptors were found to indicate significantly poorer patient prognosis (P < .001). These results suggest that CXCL12 induces EMT at least partially through cross talk between CXCR4 and c-MET signaling. In addition, changes in these pathways could have clinical importance for the treatment of gastric cancer.
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