期刊
TRAFFIC
卷 19, 期 5, 页码 301-318出版社
WILEY
DOI: 10.1111/tra.12554
关键词
lipid transfer; membrane contact sites; membrane trafficking; phosphatidylinositol; phosphoinositides; PtdIns(4)P; SAC domain
类别
资金
- Canadian Institutes of Health Research [MOP-119483, MOP-130437]
- Natural Sciences and Engineering Research Council of Canada [RGPIN-262166-10]
- Cancer Research Society [16121]
The lipid phosphatase Sac1 dephosphorylates phosphatidylinositol 4-phosphate (PI4P), thereby holding levels of this crucial membrane signaling molecule in check. Sac1 regulates multiple cellular processes, including cytoskeletal organization, membrane trafficking and cell signaling. Here, we review the structure and regulation of Sac1, its roles in cell signaling and development and its links to health and disease. Remarkably, many of the diverse roles attributed to Sac1 can be explained by the recent discovery of its requirement at membrane contact sites, where its consumption of PI4P is proposed to drive interorganelle transfer of other cellular lipids, thereby promoting normal lipid homeostasis within cells.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据