期刊
TOXICON
卷 149, 期 -, 页码 65-71出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.toxicon.2017.12.046
关键词
Bacterial protein toxin; ExoY; Pseudomonas aeruginosa; T3SS; Actin
资金
- Pasteur Paris University (PPU) International PhD Program
- CNRS
- PTR program of the Institut Pasteur [PTR425, PTR43-16]
ExoY is one of four well-characterized Pseudomonas aeruginosa type 3 secretion system (T3SS) effectors. It is a nucleotidyl cyclase toxin that is inactive inside the bacteria, but becomes potently activated once it is delivered into the eukaryotic target cells. Recently, filamentous actin was identified as the eukaryotic cofactor that stimulates specifically ExoY enzymatic activity by several orders of magnitude. In this review, we discuss recent advances in understanding the biochemistry of nucleotidyl cyclase activity of ExoY and its regulation by interaction with filamentous actin. (C) 2017 Elsevier Ltd. All rights reserved.
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