期刊
TOXICOLOGY IN VITRO
卷 48, 期 -, 页码 262-275出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tiv.2018.01.023
关键词
In vitro toxicology; Xenobiotic safety; Hepatotoxicity; 3D cell culture models; Liver spheroids
类别
资金
- BBSRC industrial CASE partnership award - Syngenta Ltd. [BB/M503435/1]
- Liverpool Centre for Mathematics in Healthcare (EPSRC) [EP/N014499/1]
- Biotechnology and Biological Sciences Research Council [1511021] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/N014499/1] Funding Source: researchfish
- Medical Research Council [MR/L006758/1] Funding Source: researchfish
- National Centre for the Replacement [NC/C011205/1] Funding Source: researchfish
- EPSRC [EP/N014499/1] Funding Source: UKRI
- MRC [MR/L006758/1] Funding Source: UKRI
Xenobiotic safety assessment is an area that impacts a multitude of different industry sectors such as medicinal drugs, agrochemicals, industrial chemicals, cosmetics and environmental contaminants. As such there are a number of well-developed in vitro, in vivo and in silico approaches to evaluate their properties and potential impact on the environment and to humans. Additionally, there is the continual investment in multidisciplinary scientists to explore non-animal surrogate technologies to predict specific toxicological outcomes and to improve our understanding of the biological processes regarding the toxic potential of xenobiotics. Here we provide a concise, critical evaluation of a number of in vitro systems utilised to assess the hepatotoxic potential of xenobiotics.
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