期刊
NATURE REVIEWS IMMUNOLOGY
卷 12, 期 11, 页码 749-761出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nri3307
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资金
- US National Institutes of Health [R01AI074699, RO1AI066232, R21AI097767, R21AI081150]
- Howard Hughes Medical Institute
During an infection, T cells can differentiate into multiple types of effector and memory T cells, which help to mediate pathogen clearance and provide long-term protective immunity. These cells can vary in their phenotype, function and location, and in their long-term fate in terms of their ability to populate the memory T cell pool. Over the past decade, the signalling pathways and transcriptional programmes that regulate the formation of heterogeneous populations of effector and memory CD8(+) T cells have started to be characterized, and this Review discusses the major advances in these areas.
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