期刊
TOXICOLOGICAL SCIENCES
卷 165, 期 1, 页码 21-30出版社
OXFORD UNIV PRESS
DOI: 10.1093/toxsci/kfy178
关键词
developmental neurotoxicity testing; DNT; neurological damage
类别
资金
- German Ministry of Education and Research [16V0899]
- Ministry of Innovation, Science and Research of North Rhine Westphalia
- German Academic Exchange Service (DAAD)
There is evidence that chemical exposure during development can cause irreversible impairments of the human developing nervous system. Therefore, testing compounds for their developmentally neurotoxic potential has high priority for different stakeholders: academia, industry, and regulatory bodies. Due to the resource-intensity of current developmental neurotoxicity (DNT) in vivo guidelines, alternative methods that are scientifically valid and have a high predictivity for humans are especially desired by regulators. Here, we review availability of stem-/progenitor cell-based in vitro methods for DNT evaluation that is based on the concept of neurodevelopmental process assessment. These test methods are assembled into a DNT in vitro testing battery. Gaps in this testing battery addressing research needs are also pointed out.
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