期刊
TISSUE ENGINEERING PART B-REVIEWS
卷 24, 期 6, 页码 443-453出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/ten.teb.2018.0018
关键词
physical microenvironment; mechanical force; topography; stem cells; inducible scaffold; tendon regeneration
类别
资金
- National Key Research and Development Program of China [2017YFA0104902, 2018YFC1105104]
- National Natural Science Foundation of China (NSFC) [81522029, 81772418, 31570987, 81330041, 81572157]
- Fundamental Research Funds for the Central Universities
Tendon injuries are common musculoskeletal system disorders, but the tendons have poor regeneration ability. To address this issue, tendon tissue engineering provides potential strategies for future therapeutic treatment. Elements of the physical microenvironment, such as the mechanical force and surface topography, play a vital role in regulating stem cell fate, enhancing the differentiation efficiency of seed cells in tendon tissue engineering. Various inducible scaffolds have been widely explored for tendon regeneration, and scaffold-enhancing modifications have been extensively studied. In this review, we systematically summarize the effects of the physical microenvironment on stem cell differentiation and tendon regeneration; we also provide an overview of the inducible scaffolds for stem cell tenogenic differentiation. Finally, we suggest some potential scaffold-based therapies for tendon injuries, presenting an interesting perspective on tendon regenerative medicine.
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