期刊
ACS APPLIED MATERIALS & INTERFACES
卷 7, 期 35, 页码 19672-19683出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b04682
关键词
electrospinning; composite fiber; post-electrospinning treatment; alkaline saponification; cellulose nanocrystals; biomimetic mineralization
资金
- Korean Ministry of Education, Science and Technology (MIST) through the National Research Foundation (NRF) [2013 R1A2A2A04015484]
- Academy and Research Institute - Korean Small and Medium Business Administration [C0208053]
- Korea Evaluation Institute of Industrial Technology (KEIT) [C0208053] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Post-electrospinning treatment is a facile process to improve the properties of electrospun nanofibers for various applications. This technique is commonly used when direct electrospinning is not a suitable option to fabricate a nonwoven membrane of the desired polymer in a preferred morphology. In this study, a representative natural-synthetic hybrid of cellulose acetate (CA) and polycaprolactone (PCL) in different ratios was fabricated using an electrospinning process, and CA in the hybrid fiber was transformed into cellulose (CL) by post-electrospinning treatment via alkaline saponification. Scanning electron microscopy was employed to study the effects of polymer composition and subsequent saponification on the morphology of the nanofibers. Increasing the PCL content in the PCL/CA blend solution caused a gradual decrease in viscosity, resulting in smoother and more uniform fibers. The saponification of fibers lead to pronounced changes in the physicochemical properties. The crystallinity of the PCL in the composite fiber was varied according to the composition of the component polymers. The water contact angle was considerably decreased (from 124 to less than 200), and the mechanical properties were greatly enhanced (Young's Modulus was improved by fold, tensile strength by 3-4 fold, and tensile stress by fold) compared to those of PCL and PCL/CA membranes. Regeneration of cellulose chains in the nanofibers increased the number of hydroxyl groups, which increased the hydrogen bonding, thereby improving the mechanical properties and wettability of the composite nanofibers. The improved wettability and presence of surface functional groups enhanced the ability to nucleate bioactive calcium phosphate crystals throughout the matrix when exposed to a simulated body fluid solution. Experimental results of cell viability assay, confocal microscopy, and scanning electron microscopy imaging showed that the fabricated nanofibrous membranes have excellent ability for MC3T3-E1 cell proliferation and growth. Given the versatility and widespread use of cellulose synthetic hybrid systems in the construction of tissue-engineered scaffolds, this work provides a novel strategy to fabricate the biopolymer-based materials for applications in tissue engineering and regenerative medicine.
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