Recent advances in C(sp3)-H bond carbonylation by first row transition metals

Carbonylation is one of the most valuable processes both in academia and industry. Direct functionalization of inert C(sp(2))-H bond into C(sp(2))-carbonyl derivatives was actively pursued over decades using noble metals. But the corresponding C(sp(3))-H bond carbonylation is a challenging area and only few examples were known till now. Utilization of first row transition metals as an alternative to their noble partners is more sustainable. In this context, use of first row transition metals for direct C(sp(3))-H bond functionalization is burgeoning as an exciting area. This digest review covers some of the recent achievements in this regard especially using Ni, Co and Cu as first row transition metals. The reported approaches are categorized in two types: directed and non-directed activation/functionalization of C(sp(3))-H bonds using carbon monoxide gas or its surrogates as a Cl source. (C) 2018 Elsevier Ltd. All rights reserved.