期刊
TETRAHEDRON LETTERS
卷 59, 期 31, 页码 2975-2978出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2018.06.047
关键词
Alstonia scholaris; lndole alkaloids; Scholarisine; Antimicrobial activities
资金
- National Key Research and Development Program of China [2017YFC1704007]
- Ten Thousand Plan, a National High-level Talents Special Support Plan
- NSFC [31500292]
Three new cage-like monoterpenoid indole alkaloids, scholarisines T-V (1-3), together with three known analogues 4-6 were isolated from the leaves of Alstonia scholaris. Among them, 2 represents a unique degraded derivative, whereas 3 shares a rare 5,16-seco lactone scaffold. The structures were mainly established by extensive spectroscopic data analyses, and their plausible biosynthesis pathway from picrinine were proposed. Compared with positive control cefotaxime, alkaloid 2 showed remarkable antibacterial activity against Bacillus subtilis with an MIC value of 3.12 mu g/mL, whereas 1-3 exhibited significant antibacterial effects on Escherichia coli with an MIC value of 0.78 mu g/mL. (C) 2018 Published by Elsevier Ltd.
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