Guanidine organocatalysis for enantioselective carbon-heteroatom bond-forming reactions

Guanidine-containing molecules have been employed as organocatalysts, and chiral guanidines have been widely explored as catalysts for mediating asymmetric reactions by constructing an asymmetric reaction environment. Currently, many guanidine-catalyzed asymmetric reactions are available, and some excellent reviews have appeared. In this Digest, we focused on recent progress in the guanidine-catalyzed asymmetric construction of C-N, C-O, C-P, and C-S bonds, especially developments since 2010. (C) 2017 Elsevier Ltd. All rights reserved.