期刊
TETRAHEDRON LETTERS
卷 59, 期 14, 页码 1385-1389出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2018.02.067
关键词
Multi-component reaction; 5-Substituted 1H-tetrazole; Aldehyde; Cerric ammonium sulphate
资金
- CSIR, New Delhi
A versatile, robust and efficient strategy for the synthesis of vast range of highly functionalized 5-substituted 1H-tetrazole derivatives by using one pot three-component synthesis from various aldehydes, hydroxylamine hydrochloride and sodium azide in presence of a catalytic amount of ceric ammonium sulphate, a non toxic, easily available, inexpensive, unexplored and reusable catalyst is reported. This one-pot synthesis has several advantages such as mild reaction conditions, shorter reaction time, low catalyst loading, good to moderate yields and functional group tolerance making this methodology practically feasible. The synthesized compounds were characterized by H-1 NMR, C-13 NMR and HRMS. (C) 2018 Elsevier Ltd. All rights reserved.
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