期刊
TETRAHEDRON
卷 74, 期 15, 页码 1868-1879出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2018.02.054
关键词
Pyrazole; Triazine; Purine isostere; Pyrazolo[1,5-a][1,3,5]triazine; Multicomponent reaction; Dynamic NMR spectroscopy
资金
- Ministry of Higher Education, Malaysia
A series of 5-aza-9-deaza- analogues of purine was effectively prepared using highly selective annulation of 1,3,5-triazine ring onto 5-aminopyrazole-4-carboxylates via a one-pot, multicomponent, microwave-assisted approach. The products were obtained in good yields and high purity. This catalyst-free method was demonstrated to be scalable and highly reproducible in different microwave reactors. Some structural features of the prepared compounds were studied in details using dynamic NMR spectroscopy and X-ray crystallography. (C) 2018 Elsevier Ltd. All rights reserved.
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