期刊
TETRAHEDRON
卷 74, 期 38, 页码 4927-4957出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2018.06.015
关键词
3-Hydroxyoxindole; 3-Aminooxindole; Asymmetric catalysis; Organocatalysis
资金
- Fundacao para a Ciencia e Tecnologia (FCT) through the Catalysis and Sustainability doctoral program (CATSUS) [PD/BD/128490/2017]
- FCT - Foundation for Science and Technology [UID/QUI/0619/2016]
Several oxindole derivatives, of natural or synthetic origin, have been identified as medicinally appealing compounds, with a plethora of bioactivities reported. Chiral 3-hydroxy and 3-aminooxindole scaffolds have captured the attention of several research groups, due to their importance in drug discovery. In this review, we systematically address the wide variety of asymmetric catalytic methodologies employed in the preparation of these relevant chiral scaffolds, present in many biologically active compounds and/or natural products. Special focus will be given to the nature of the catalyst used. (C) 2018 Elsevier Ltd. All rights reserved.
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