期刊
TETRAHEDRON
卷 74, 期 26, 页码 3314-3317出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2018.04.052
关键词
Palladium catalysis; Reductive Heck; Nanoparticles
资金
- Indiana University
- NSF CAREER Award [CHE-1254783]
- Amgen
- Eli Lilly Co.
- Amgen Young Investigator Award
- Vice Provost for Research through the Research Equipment Fund
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1254783] Funding Source: National Science Foundation
The reductive-Heck reaction offers a unique entry to formal Csp(2)-Csp(3) cross-coupling reactions that proceed in the absence of a main group organometallic coupling partner. Consequently, further development of new variants would be transformative. Unfortunately, controlling the relative rates of the organopalladium intermediates has proven difficult with homogenous, single-site Pd catalysts. This work describes a selective reductive Heck reaction catalyzed by Pd-nanoparticles. The reaction works well with electron-deficient aryl triflates at room temperature in the absence of ligands. This work addresses some of the challenges found in the reductive-Heck literature. (C) 2018 Published by Elsevier Ltd.
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